%0 Journal Article %A Salim Zaman %A Anilbaran Singhamahapatra %A Apurba Mukherjee %A Joyashree Banerjee %T Study of pulmonary function in type2 diabetes mellitus and its changes with change in duration and glycemic control %D 2012 %J European Respiratory Journal %P P258 %V 40 %N Suppl 56 %X Rationale: Diabetes mellitus(DM) is a metabolic disease causing changes in multiple systems, and pulmonary system is not an exception to this rule. As the prevalence of T2DM is increasing, the potential implication of diabetic status affecting pulmonary system demand attention.Objectives: To assess the pulmonary function in Type2 DM patients and its variation(if any) with Duration of disease and level of glycemic control.Methods: A comparative study was conducted including 60 T2DM patients and 60 age and sex matched controls. The special investigations were done: 1. HBA1c, 2. PFT by flow sensitive spirometer 3.DLCO by single breath technique. Grouping of cases were done according to duration of T2DM (Gr.Ia=≤5yr, Gr.Ib=6-10yr, Gr.Ic=>10yr) and HBA1c level(Gr.IIa=<6,Gr.IIb=6-7,Gr.IIc=>7). Results: Significant changes in PFT parameters and Diffusion capacity-DLCO% and DL/VA% in cases compared to controls.There was significant(P<0.05) decrease in FVC%, DLCO% and DL/VA% & increase in FEV1/FVC% in Gr.Ic and Gr.IIc compared to Gr.Ia & Gr.IIa. There was negative correlation of FVC%(r=-0.53),DLCO%(r=–0.66,) and DL/VA%(r=–0.68) with duration & with HBA1c level- FVC%(r=–0.50), DLCO%(r=–0.65) and DL/VA%(r=–0.62) with HBA1c level where as FEV1/FVC% was positively correlated with duration(r=+0.39) and HBA1c(r=+0.50).Conclusion: There is significant changes of pulmonary functions with changes in duration and glycemic control, which may be due to non enzymatic glycosylation of tissue proteins and chronic diabetic microangiopathy. So, in routine screening by doing PFT, we can reduce mortality and morbidity of the patients(type2DM) due to subclinical or overt pulmonary dysfunctions. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P258.full.pdf