RT Journal Article SR Electronic T1 Potential angiogenic biomarkers in patients with non small cell lung cancer: Possible implications JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4220 VO 40 IS Suppl 56 A1 Soad Abdel Ghani A1 Nagla Elmelegy A1 Aliae Mohamed-Hussein A1 Randa Hanna YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P4220.abstract AB To date, no single agent has gained a sufficient prognostic significance for NSCLC patients. So, there is an urgent need for new innovative biomarkers in NSCLC.The present study was designed to: 1) Evaluate the role of Nitric Oxide (NO), Sialic Acid (SA) and Glutathione S-Transferase (GST) as prognostic indicators in NSCLC.2) Correlate the above parameters levels with the clinicopathological status of the patients.The study included 30 patients with newly diagnosed histopathologically confirmed NSCLC, as well as 10 healthy volunteers with matched age and sex as controls. Blood samples and lung tissue biopsies were taken from all subjects on admission and after chemotherapy with and without Nimesolide (Cox-2 inhibitor).Results: Serum and tissue levels of NO, SA and GST activities were significantly higher in NSCLC patients compared to controls. These levels decreased significantly after chemotherapy (specially if Cox-2 inhibitors were added). The serum and tissue levels of the studied parameters decreased significantly in the responders compared to resistant cases.In conclusion, NO, SA, besides GST correlated significantly with the clinicopathological status of NSCLC patients and are considered cheap sensitive prognostic biochemical indices.