PT  - JOURNAL ARTICLE
AU  - Soad Abdel Ghani
AU  - Nagla Elmelegy
AU  - Aliae Mohamed-Hussein
AU  - Randa Hanna
TI  - Potential angiogenic biomarkers in patients with non small cell lung cancer: Possible implications
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4220
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4220.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4220.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - To date, no single agent has gained a sufficient prognostic significance for NSCLC patients. So, there is an urgent need for new innovative biomarkers in NSCLC.The present study was designed to: 1) Evaluate the role of Nitric Oxide (NO), Sialic Acid (SA) and Glutathione S-Transferase (GST) as prognostic indicators in NSCLC.2) Correlate the above parameters levels with the clinicopathological status of the patients.The study included 30 patients with newly diagnosed histopathologically confirmed NSCLC, as well as 10 healthy volunteers with matched age and sex as controls. Blood samples and lung tissue biopsies were taken from all subjects on admission and after chemotherapy with and without Nimesolide (Cox-2 inhibitor).Results: Serum and tissue levels of NO, SA and GST activities were significantly higher in NSCLC patients compared to controls. These levels decreased significantly after chemotherapy (specially if Cox-2 inhibitors were added). The serum and tissue levels of the studied parameters decreased significantly in the responders compared to resistant cases.In conclusion, NO, SA, besides GST correlated significantly with the clinicopathological status of NSCLC patients and are considered cheap sensitive prognostic biochemical indices.