TY - JOUR T1 - The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2322 AU - Dean Mills AU - Michael Johnson AU - Martin McPhillimey AU - Neil Williams AU - Javier Gonzalez AU - Yvonne Barnett AU - Sharpe Graham Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2322.abstract N2 - The plasma concentration of interleukin-6 (IL-6) increases during cycling exercise (EX) (Starkie et al. J. Physiol 2001; 533:585-591) and inspiratory resistive breathing (IRB) (Vassilakopoulos et al. Am. J. Physiol 1999; 277:R1013–R1019). Whether inspiratory muscle training (IMT) can attenuate the magnitude of the IL-6 response to EX and volitional hyperpnoea (VH) rather than IRB is unknown. Therefore, we tested the hypothesis that IMT would reduce the IL-6 response to EX and/or VH.Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Before and after training, participants undertook three 1 hour experimental trials on separate days: (i) passive rest; (ii) EX; and (iii) VH. EX was performed at maximum lactate steady state power. In VH, participants voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern attained during EX.IL-6 peaked immediately after EX for both the IMT and PLA groups (6.75 ± 1.6 and 5.64 ± 1.76 pg·mL-1). Following training, this response was reduced (-33%; P=0.027) for the IMT but not the PLA group. Blood lactate concentration ([Lac-]B) during EX was also reduced (-35%; P=0.009) for the IMT group only. IL-6 and [Lac-]B increased (P<0.05) during VH in both groups, but there was no effect of training on these responses. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest.In conclusion, 6 weeks of IMT reduces IL-6 during EX but not VH. The reduction in IL-6 concentration following IMT may be related to a decreased carbohydrate utilisation as indicated by the post-IMT reduction in [Lac-]B during EX but not VH. ER -