TY - JOUR T1 - Safety aspects of endobronchial valve application in the complex treatment of patients with cavitary drug-resistant pulmonary tuberculosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2701 AU - Sergey Sklyuev AU - Denis Krasnov Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2701.abstract N2 - Aims: To evaluate the safety of endobronchial valve application in TB patients.Methods: In total, 68 patients with drug-resistant destructive pulmonary tuberculosis were taken into the study, they were randomly divided on two groups - one for 33 patients for endobronchial-valve installation (EBV) and another – for 35 to receive standard treatment (control group).Results: On Day 2 of the study, 12 (36.7%) patients from EBV-group had developed sparse, dry cough, in the control group - 2 (5.7%) patients (p = 0.0019). 3 (9.1%) of patients from EBV-group were with worsening of COPD symptoms and required symptomatic treatment, vs. 0 cases in the control group (p = 0.008). All these manifestations had been happened within 2 weeks of treatment. During assessment of the bronchial tree after 8 months in patients from EBV-group we revealed proliferation of granulation tissue in the targeted bronchi in 100% of the cases, of whom 24 (72.7%) granulations were big (closing over 50% of the lumen of the bronchus). After 10 months, during bronchoscopy in patients with EBV-group we found scars of the bronchus wall 100% of the cases, in 17 (51.5%) we revealed circular stenosis of the bronchi which reduced over 50% of the lumen of the bronchus, in 9 of these cases (27.3%) the lumen of the blocked bronchus was less than 1 mm in diameter. None of these changes were detected in the control group.Conclusions: Endobronchial-valve treatment leads to the corrected without affecting the course of the disease complications in the first two weeks of treatment, and causes scar deformation of the targeted bronchus. ER -