TY - JOUR T1 - Factors influencing change in baseline vitamin D level in mycobacterial infection JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2576 AU - Gemma Hawthorne AU - Alice Turner AU - Heinke Kunst AU - Martin Dedicoat AU - David Thickett Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2576.abstract N2 - BackgroundVitamin D may be an agent, of broad relevance in the treatment of infectious disease because of its immunomodulatory properties.MethodsIn an ongoing open label observational trial, baseline bloods, vitamin D levels, sputum smear and culture results, radiological changes and TB score were recorded in patients with mycobacterial infection.Each patient was supplemented with 100,000 units of cholecalciferol at 0, 8 and 16 weeks.ResultsThe mean age of patients recruited (n=42) was 36 years (M:F 27:15), with pulmonary disease (n=29) or extrapulmonary disease (n=13). There was a non-significant difference in vitamin D levels between the groups.Pre supplementation median vitamin D levels were 11.9 nmol/l (mean 16.96 nmol/l, 92.9% with 25(OH)D3 levels <50nmol/l. At week 8 post supplementation levels had risen to median 44nmol/l (mean 43.9 nmol/l). There was a significant difference in vitamin D levels pre and post supplementation (p=0.00), with a significantly higher percentage rise in vitamin D levels in patients who were severely deficient (<20nmol/l) (p=0.01).There was no correlation between vitamin D and DBP, antimicrobial product (LL37) levels or TB score at baseline measurement.ConclusionsSupplementation with 100 000 units of cholecalciferol does not result in sufficient levels (>50nmol/l) at 8 weeks in all patients with just 65% attaining levels >50nmol/l. However, there is a statistically significant rise in levels of vitamin D in those supplemented between week 0 and week 8.Patients with mycobacterial infection with vitamin D deficiency may benefit from higher initial doses to obtain sufficiency. ER -