PT  - JOURNAL ARTICLE
AU  - HamidReza Jabbardarjani
AU  - Ramin Sami
AU  - Arda Kiani
AU  - Mohammadreza Masjedi
TI  - Comparison of conventional forceps biopsy and cryobiopsy in endobronchial lesions
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3601
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3601.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3601.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background and objectives:Forceps biopsy has long been the standard method of extracting samples from endobronchial lesions,however diagnostic yield of the specimen obtained by this method(72%)is not very desirable due to small size and artifact.Therefore,in order to increase the diagnostic yield in endobronchial lesions as well as diminish the complications we evaluated a new technique called cryobiopsy(using flexible cryoprobes to obtain frozen samples).Methods: All patients with endobronchial lesion except for vascular lesions referred to Intervention ward of Masih Daneshvari Hospital were included in this study.For each patient,6 specimen were obtained by conventional forceps,and 2 were extracted through cryobiopsy,one of them 3 seconds after freezing (CB3),and the other one 5 seconds after freezing(CB5).Bleeding during the procedure,and diagnostic yield of the samples were evaluated closely.Results: Of all 30 patients,diagnosis was achieved for 27 patients(90%).Diagnostic rate of forceps biopsies was 67%,while this rate was 80% and 78% for CB3 and CB5 respectively.Although there was no significant difference between these three rates, total diagnostic yield of both CB3 and CB5 together was significantly higher than conventional biopsy (P-value=0.016).Severe bleeding requiring APC to be controlled occurred in 2 cases during CB5,while no major hemorrhage happened during forceps biopsy.Conclusion: According to our results,obtaining at least two samples from endobronchial lesions by cryobiopsy technique can lead to a higher rate of diagnosis compared with 6 samples by forceps biopsy.However,duration of freezing(3 or 5 seconds)does not have a significant impact on the quality of specimen.