@article {MalpassP2154, author = {Jamie Malpass and Mark Nagel and Valentina Avvakoumova and Rubina Ali and Heather Schneider and Jolyon Mitchell}, title = {Not all antistatic valved holding chambers have equivalent performance: An example why each valved holding chamber (VHC)-inhaler combination should be considered unique}, volume = {40}, number = {Suppl 56}, elocation-id = {P2154}, year = {2012}, publisher = {European Respiratory Society}, abstract = {RATIONALE: Electrostatic charge mitigation by the use of charge dissipative materials with VHCs is common, since initial pre-washing can be avoided. We compared {\textquoteright}antistatic{\textquoteright} VHCs; Optichamber{\textregistered} Diamond{\textregistered} (OD), Phillips Healthcare with AeroChamber Plus{\textregistered} Flow-Vu{\textregistered} (AC Flow-Vu) Trudell Medical International) (n=4 devices/group), to determine suitability for patients delaying inhalation post-actuation.METHODS: An abbreviated Andersen impactor that determined fine particle mass \< 4.7 {\textmu}m at 28.3 L/min (FPM\<4.7{\textmu}m) was used with an apparatus simulating 2, 5 and 10 s delay intervals following pMDI actuation (Flovent{\textregistered}, GSK plc, 125 {\textmu}g/actuation fluticasone propionate (FP)). This approach conforms to guidance from European authorities that testing of VHCs should simulate delayed inhalation. Assay for FP was undertaken by HPLC-UV spectrophotometry. Measurements without delay were undertaken to assess mass recovery for FP, validating the procedure. All values are mean{\textpm}SD.RESULTS: Mass recoveries (131.5{\textpm}2.9 and 130.7{\textpm}3.8 {\textmu}g/actuation for the OD and ACPlus VHCs respectively) were close to label claim, validating system suitability. The variation of FPM\<4.7{\textmu}m with delay interval is shown in the Table.View this table:Relative Depletion of FPM\<4.7{\textmu}mThe ratio FPM\<4.7{\textmu}m-ACPlus/FPM\<4.7{\textmu}m-OD) increased from 1.2 (2-s) to 1.4 (5-s) and to 1.6 (10-s), demonstrating faster depletion of the therapeutically beneficial medication from the OD.CONCLUSION: Not all VHCs manufactured from anti-static materials provide optimum performance for patients who have poor coordination.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P2154}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P2154.full.pdf}, journal = {European Respiratory Journal} }