%0 Journal Article %A Monika Kosacka %A Anna Korzeniewska %A Renata Jankowska %T Osteoprotegerin, body composition and cardiovascular risk in sleep apnea syndrome %D 2012 %J European Respiratory Journal %P P3810 %V 40 %N Suppl 56 %X Obstructive sleep apnea syndrome (OSAS) is a frequent disease associated with increased risk of cardiovascular disorders. The aim of this study was the evaluation of changes in osteoprotegerin serum levels and in body composition parameters in patients with sleep apnea syndrome.We examinated 47 patients with OSAS (mean age 55,42 ±7,91, mean AHI 32,76 ±19,98) and 29 persons from control group (mean age 49,48 ±13,68). All subjects underwent bioelectrical impedance analysis with a single-frequency bioimpedance analyzer (Model BIA 101 Akern) and polysomnography Grass Aura Lite. The osteoprotegerin serum level was measured using a ELISA kit: Human Osteoprotegerin (R&D Systems).We didn't showed either differences in osteprotegerin serum levels between OSAS patients and control group (4,696 vs 4,631 pmol/l, p=0,680) nor correlations between osteoprotegerin and AHI (p=0,484, R=0,08). Moreover we didn't find changes in osteprotegerin levels in OSAS patients with diabetes (p=0,251), with hypertension (0,911) or ischemic heart disease (0,876).We observed higher BMI in OSAS patients (p=0,009),but from all body composition parameters we revealed only lower phase angle in OSAS patients (5,65, vs 5,87,p=0,047). We evaluated the relationships between osteoprotegerin and body composition parameters and we found only tendency, that osteoprotegerin level correlated negative with muscle mass percentage (MM%) (p=0,069, R=-0,209) and positive with fat mass percentage FM%. CRP was significant higher in OSAS than in control group (6,59 vs 3,85 p=0,006).R=0,198,p=0,08), but we didn't find correlations between osteoprotegerin and CRP (p=0,929, R=0,010).Our study didn't show changes in osteoprotegerin in OSAS patients. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P3810.full.pdf