TY - JOUR T1 - FeNO measurements in pregnant asthmatic women JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2210 AU - Marita Nittner-Marszalska AU - Anna Dor-Wojnarowska AU - Hanna Marszalska AU - Robert Pawlowicz AU - Maria Kraus-Filarska AU - Bernard Panaszek Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2210.abstract N2 - BACKGROUND: The measurement of severity and control of asthma can be based on subjective or objective measures. It has been advocated that fractional exhaled nitric oxide (FeNO) can be used to monitor airway inflammation as it correlates with some markers of asthma.The aim of our study was to assess the clinical usefulness of the assessment of FeNO for monitoring asthma during pregnancy.METHODS: It was a prospective cross-sectional study. We evaluated the medical data of 72 pregnant asthmatic women: FeNo results, atopic status, spirometry and ACT (asthma control test) (monthly, 257 visits in all; first visit between 8-22 Hbd). We assessed asthma severity on the basis of anamnesis considering mean doses of inhaled glucocorticosteroids taken by the patients and a management approach based on control according to the newest guidelines of Global Initiative for Asthma (GINA) throughout the last three months before pregnacy.RESULTS: We did not find correlation between FeNO levels at visit one (pregnancy) and asthma severity before pregnancy (p=0.97). In 22 women with worsening asthma during pregnancy, the mean FeNO during visits without asthma symptoms and with asthma worsening did not differ. A comparison of FeNO levels in the groups of women with well controlled asthma during pregnancy and FeNO with visits without asthma symptoms in the group of women with at least one asthma exacerbation did not differ. There was a statistically significant but low correlation between FeNO levels and ACT total scores results, and FeNO levels and FEV1 (r=0,21 and r=0,25 respectivelly).CONCLUSIONS: FeNO does not seem to be clinically applicable to predict asthma prognosis during pregnancy, esspecialy beacouse of its high coefficient variation. ER -