PT  - JOURNAL ARTICLE
AU  - Violeta Cojocariu
AU  - Adriana Sorete Arbore
AU  - Rodica Sorete Arbore
TI  - Childhood tuberculosis in Iasi County, Romania: 10 years review
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P2678
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P2678.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P2678.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - TB represents a major healthcare problem in Romania.The incidence of TB in children registered, in Iasi County, significant annual changes (47.4%ooo in 2001 to 26%ooo in 2010).Aim: analysis of TB characteristics in children in a high incidence TB County.Method: retrospective study of TB cases in persons 0-14 years old, registered and treated 2001- 2010. WHO recommendations were used.Demographic data, TB contact, site of TB, bacteriological status, co morbidities and treatment results were followed up.Results: 763 children were notified in 10 years, males -52%; 70.2% from rural area,TB contact – 47.5%.TB meningitis – 4.8%(37), disseminated TB - 0.9% (7).HIV positive were 5.5%.88.3% cases were extra pulmonary TB, 11.6% pulmonary TB.Bacteriological status: 132 Mt culture positive (19.2%). Out of 63 Mt strains with DST, 84.1% were susceptible.Treatment results: successful 9.9%, died 2.6%.Treatment results in 10 MDRTB cases: 70% success, 10% default and 20% in treatment.Out of 42 HIV positive TB cases: 71.4% were successfully treated, 21.4% died, 2.3% failed, 2.3% defaulted.Conclusions:1. High TB incidence in childhood, important percent of bacteriological confirmation and severe TB forms point out the gravity of TB endemic in this area;2. Death rate – 2.6% in this cohort was registered mainly in HIV co infected cases and TB meningitis;3. Despite of co infection and MDRTB, the success rate was high: 92.9%;4. TB in child hood is an important marker for TB endemic in Iasi area and pulmonologists need to focus on accurate diagnosis and treatment.