TY - JOUR T1 - Pseudomonas infection risk in bronchiectasis: A retrospective cohort analysis of longitudinal microbiology in 174 patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2559 AU - Hannah Jary AU - Jim MacFarlane AU - Katy Hester AU - Paul McAlinden AU - Therese Small AU - John Perry AU - Kathy Walton AU - Anthony De Soyza Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2559.abstract N2 - Background: Pseudomonas aeruginosa (PA) is a key pathogen in bronchiectasis, a disease characterised by recurrent infections. However, little is known of the infection risk in bronchiectasis stratified by levels of airflow impairment.Aims: To explore the relationship between longitudinal airway microbiology in bronchiectasis and clinical markers of disease severity.Methods: A retrospective database review of consecutive adult patients attending a UK bronchiectasis clinic from 2007 and 2010. We stratified patients by lung function (FEV1 % predicted: severe ≤40%; moderate 41-79%; mild ≥ 80%).Results: 174 patients were identified with mean microbiological data for 6 years. Mean exacerbation frequency in 152 patients was 4.17/year; 70% reported 3+ exacerbations per year. Patients had a mean FEV1 % predicted of 65.7 (±30.1), with minimal, moderate and severe airflow limitation found in 27.0%, 50.0% 21.8% of patients respectively (2 patients had missing data). Aetiology of bronchiectasis was found to be idiopathic or post-infectious in 58.8% and COPD in 9.2%. Isolation of Haemophilus influenzae (HI) was more common than of PA (52.9% vs 47.1%), but persistent colonisation was more common with PA. Of patients with minimal airflow limitation, 31.9% isolated PA compared to 71.1% of those with severe airflow limitation. Hospital admissions but not self reported exacerbations were more common in the PA infected group.Conclusions: PA is associated with greater persistence rates and more hospital admissions than HI. PA infection occurs across all strata of lung function impairment. Careful microbiology follow up is required even in those with preserved lung function. ER -