@article {Bridevaux3306, author = {Pierre-Olivier Bridevaux and Jean-Marie Tschopp and Chetna Bhatia and Isabelle Fr{\'e}sard and Fr{\'e}deric Triponez and Jean-Marie Schnyder and John Robert and Thierry Rochat and Marc Licker}, title = {Effect of pre-operative short-term rehabilitation on peak VO2 in patients with NSCLC}, volume = {40}, number = {Suppl 56}, elocation-id = {3306}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Preoperative fitness is best assessed with cardio-pulmonary exercise testing (CPET) in patients with non-small cell lung cancer (NSCLC). Peak Oxygen consumption (VO2 peak) is predictive of short-term complications after thoracic surgery. Feasibility and effect of short-term (2 to 3 weeks) rehabilitation on fitness and short-term outcomes are unknown.We planned a pragmatic, randomized controlled trial (RCT) comparing short-term rehabilitation (R) with usual care (UC) in patients with operable NSCLC.Method: This ongoing study enrolls patients after baseline CPET from 2 centres in Switzerland. Intervention: preoperative three-times a week, intensive, respiratory physiotherapist supervised interval training. Controls: usual careOutcomes: post-operative complication rate, short-term change in VO2 (baseline and immediately before surgery), long-term fitness and quality of life.Results: Up to december 2011, 65 patients were randomized, R n=31, UC n=34 (mean age 63.4 [10.5], FEV1 86.7\% [23.5], DLCO 70.5\% [19.0], VO2 peak 19.5 ml/min/kg [5.7] watt peak 86 W[38], 6MWT 370 m [101]). As reassessed immediately before surgery VO2 peak (+2.3 [0.7] ml/min/kg, p=0.04), watt (+15.5 [4.6] W, p=0.04), 6MWT (+87 [15.5] m, p\<0.01) improved in R but not in UC patients.Conclusion: This interim analysis shows that short-term intensive rehabilitation is feasible and improves fitness before surgery in patients with resectable NSCLC.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/3306}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/3306.full.pdf}, journal = {European Respiratory Journal} }