PT - JOURNAL ARTICLE AU - Borislav Kamenov AU - Hristina Stamenkovic AU - Tatjana Stankovic AU - Aleksandar Kamenov AU - Svetlana Kamenov TI - Day care attendance, recurrent infections, wheezing and eczema DP - 2012 Sep 01 TA - European Respiratory Journal PG - P1104 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P1104.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P1104.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: The majority of studies of recurrent infections, wheezing and eczema are seeking for genetic background, possible immunodeficiency, and atopy. Exposure to pathogens, particularly viruses seems to be very important for aberrations in the development of the immune system that may lead to chronic conditions later in life.Methods: In order to determine the importance of day care attendance in the pathogenesis of recurrent infections, wheezing and eczema, children aged one to two years, with recurrent infections, wheezing or/and eczema and attending day care were analyzed. The parents from all children were advised to withdraw from day care attendance. On the criterion of the acceptance of withdrawing patients were divided in two groups: I that accepted (53) and II that did not accept such advice (32). Both groups were followed up next 12 months, for the incidence of infections, wheezing and eczema episodes. The excluding criteria for the study were: intolerance/allergy to cow milk and other nutritional allergens, treatment with steroids and antyleukotriens.Results: During one year follow up in the group that was withdrawn from day care attendance the symptom scores related to respiratory infections reduced by 76%, wheezing by 36% and eczema by 29%.Conclusion: Our results indicate that withdrawing from day care attendance reduces the symptom scores related to recurrent infections, wheezing and eczema episodes. This suggests that viral infections, the most frequent infections in this age are important for inappropriate development of the immune system and may be a pathogenetic factor in chronic inflammation, asthma and eczema development.