RT Journal Article
SR Electronic
T1 The indices of body composition (IBC) consideration the changes of serum TNF-α, hormones and oxygen saturation (SO2%) in men with chronic obstructive pulmonary disease (COPD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2234
VO 40
IS Suppl 56
A1 Sviatlana Lemiasheuskaya
A1 Alexander Makarevich
A1 Natalia Vasileva
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2234.abstract
AB Aim and objectives: to analyze dynamics of changes of IBC and the relationships between IBC and TNF-α, leptin (L), parathyroid hormone (PTH), testosterone free(TF), markers of bone metabolism, SO2%.Material and Methods: Bone mineral content (BMC), Fat mass (FM) and Lean mass (FFM, excl. BMC) were detected by DEXA. We obtain FMI, FFMI and BMCI indices. We examined 83 male pts (aged 40-70) and control group: 15 healthy comparable men. The pts were subdivided into 3 groups according to severity (GOLD).Results: The value of FFMI was significantly decreased in the 3rd group (17.7 kg/m2) vs. the control (20.3), the 1st and 2nd groups (20.5 and 20.2 respectively). The significant positive correlations were detected between FMI and L, beta-crosslaps levels and negative one – with TF (r=0.31, r=0.31, r=-0.38 respectively). The TF level was lower (p< 0.05) in all pts group vs. the control (6.7 and 10.5 pg/ml respectively). The TNF-α level was inversely related to FFMI (r= - 0.30, p=0.03). BMCI was significantly and positive correlated with SO2% (r=0.40) and the level of PTH (r=0.54). FMI, FFMI and BMCI were correlated with pack/years index (r=- 0.37; r=- 0.37 and r=- 0.30 respectively). Pts of the 3rd group had lower FMI (4.68 kg/m2) than pts with early COPD stages (8.28 and 9.72 kg/m2 in the 1st and 2nd groups; p< 0,001). The BMCI level in 1st and control groups was the same and was significantly higher (1.06 kg/m2) vs. the 2nd and 3rd groups (1.00 and 0.89 kg/m2 respectively).Conclusions: The dynamic of IBC in these pts depends on levels of severity of systemic inflammation, hypoxia, and hormonal changes.