PT - JOURNAL ARTICLE AU - Elisabeth Romme AU - Lisa Edwards AU - MIchelle Williams AU - John Murchison AU - Martin Connell AU - Alvar Agusti AU - Stephen Rennard AU - Per Bakke AU - Frank Smeenk AU - Emiel Wouters AU - Erica Rutten AU - William MacNee TI - Low CT bone radio density is associated with adverse clinical features and increased coronary artery calcification in COPD DP - 2012 Sep 01 TA - European Respiratory Journal PG - P209 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P209.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P209.full SO - Eur Respir J2012 Sep 01; 40 AB - In addition to its pulmonary effects, COPD is characterised by extra pulmonary effects such as osteoporosis and cardiovascular disease. Accumulating evidence shows that osteoporosis and cardiovascular disease are related. However, data on this relationship in COPD are scarce. Therefore, we evaluated CT measured bone radio density and its relationship with coronary artery calcification score (CACS), as a marker for cardiovascular disease, in a well-characterised COPD cohort (ECLIPSE study).Bone radio densities of T4, T7 and T10 and the CACS (measured as the Agatston and MESA scores) were assessed on chest CT scans in 1343 subjects (COPD n=998, 61% males, age 63.3±6.9yrs, FEV1% pred 49.3±16.2; smoker controls n=228, 58% males, age 54.4±8.8yrs, FEV1% pred 109.3±11.7; non-smoker controls n=117, age 53.3±9.0yrs, FEV1% pred 114.7±13.6).Bone radio density (BRD) was lower in COPD patients than smokers or non-smoker controls (163.4±48.6 vs 185.1±89.8 vs 213.8±50.2 HU, p<0.001). In the COPD group, BRD correlated with age (r=-0.267, p<0.001), FEV1 % pred (r=0.081, p=0.010), FEV1/FVC (r=0.100, p=0.002), BMI (r=0.231, p<0.001), mMRC (r=-0.089, p=0.006), BODE (r=-0.116, p<0.001), exacerbation rate (r=-0.088, p=0.006), emphysema (r=-0.126, p<0.001), Agatston score (r=-0.252, p<0.001) and MESA score (r=-0.197, p<0.001). However, BRD in COPD patients did not correlate with pack years smoked (p=0.398) or decline in FEV1 (p=0.546). Comorbid heart failure in COPD patients was associated with lower BRD (149.4±44.5 vs 165.1±48.5 HU, p=0.025).We show in a COPD cohort that low bone radio density is associated with adverse clinical features and with high CACS.