TY - JOUR T1 - The development of pulmonary hypertension after first episode of acute pulmonary embolism and related risk factors JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1494 AU - Shuai Zhang AU - Zhenguo Zhai AU - Yuanhua Yang AU - Tuguang Kuang AU - Chen Wang Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1494.abstract N2 - Background: Part of patients with acute pulmonary embolism(PE) will develop into pulmonary hypertension(PH) including chronic pulmonary thromboembolic hypertension(CTEPH). Related risk factors need to be addressed to guide clinical practice.Objectives: To investigate the incidence of PH after PE and related risk factors.Methods: Consecutive patients diagnosed as acute PE admitted to our institute from 2006 to 2010 were included. All the patients were followed till Dec 2011. During the follow-up, patients with PH showed in echocardiogram, defined as estimated systolic pulmonary artery pressure(sPAP) over 50mmHg, received right heart catheterization to confirm the diagnosis of CTEPH.Results: 612 patients were included and the median follow-up period was 36 months. All-cause mortality was 17.3%. 15 patients developed into PH and 10 were diagnosed as CTEPH. The 1-, 2- and 5-year cumulative incidences of PH were 1.0%(95%CI 0.2%-1.8%), 1.3%(95%CI 0.3%-2.3%) and 3.5%(95%CI 1.5%-5.5%) respectively. Patients with varicose vein of lower limbs(HR 5.480,95%CI 1.058-28.385) and existence of PH at the beginning(HR 10.743,95%CI 2.315-49.852) had higher risk in developing into PH.Conclusions: CTEPH is a serious complication in a significant number of PE cases. History of varicose vein of lower limbs and estimated sPAP over 50mmHg at the first episode of PE seem to predict the risk of CTEPH in long-term follow-up. ER -