RT Journal Article
SR Electronic
T1 Effects of CETP and APOE polymorphisms on lipoprotein levels in patients with obstructive sleep apnea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1886
VO 40
IS Suppl 56
A1 Radovan Tisko
A1 Zuzana Sopkova
A1 Viera Habalova
A1 Zuzana Dorkova
A1 Eva Slaba
A1 Martin Javorsky
A1 Ivan Tkac
A1 Ruzena Tkacova
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1886.abstract
AB Rationale. Cholesterol ester transfer protein (CETP) and apoliprotein E (APOE) polymorphisms were related to serum lipids in association studies. In a mouse model of obstructive sleep apnea (OSA) hypoxia inhibited clearance of triglyceride-rich lipoproteins. Since hypoxia might interfere with genetic background to affect lipid levels, we examined effects of interactions between CETP and APOE variants and hypoxia on serum lipids in OSA patients.Methods. 634 adult subjects evaluated for suspected OSA underwent overnight polysomnography. The association of HDL-cholesterol (HDLC), triglycerides (TG) and LDL-cholesterol (LDLC) with OSA-related hypoxia reflected by oxygen desaturation index (ODI) was examined and adjusted for relevant covariates.Findings. Patients were 69.1% male (age 51.1±11.2 years, apnoea-hypopnoea index 30.4±29.9). In univariate analyses, HDLC was related to the both ODI and CETP polymorphism (R=-0.196, p<0.001; R=0.123, p=0.002). In multivariate analysis only CETP genotype remained associated with HDLC (R2=0.185, p=0.002) and no interaction between CETP variant and ODI was observed. In contrast, TG were related to ODI and APOE polymorphism in the univariate analyses (R=0.284, p<0.001; R=0.100, p=0.013), and also after adjustments (R2=0.382, p=0.046, p=0.002). Significant interaction between APOE genotype and ODI was observed with respect to TG levels (p=0.010 for the interaction term APOE*ODI).Conclusion. Our findings support the role of CETP and APOE polymorphisms in atherogenic dyslipidaemia in OSA patients, and suggest the presence of an interaction between hypoxia and APOE genotype to affect TG levels.Funding. APVV-0134-11, VEGA 1/0111/12, Slovakia.