TY - JOUR T1 - Exercise testing confirms the role of impaired central circulatory function and elevated right ventricular stroke work index in patients undergoing lung transplantation JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - 3312 AU - Matthew Bartels AU - Hilary Armstrong AU - Tomoko Kato AU - Matthew Bacchetta AU - Christian Schulze Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/3312.abstract N2 - Introduction: Right ventricular (RV) workload assessed by RV Stroke Work Index (RVSWI) is a negative predictor of outcome in acute respiratory failure. Cardiopulmonary exercise testing (CPET) may have a role in detecting central circulatory impairment (CCI) in patients before lung transplantation (LTx) at risk for impaired RV function.Aims and Objectives: To demonstrate correlation of ventilatory inefficiency (VI) on CPET for detection of CCI in patients before LTx with RVSWI.Methods: 172 patients undergoing evaluation for LTx who had CPET and right heart catheterization were included. RVSWI (stroke volume index*(mean pulmonary arterial pressure - mean right atrial pressure)*0.0136) was calculated from invasive hemodynamic data. Pearson's correlation, significance 0.05, was assessed between RVSWI and CPET parameters.Results: RVSWI correlates highly with VI and inversely with hemodynamics on CPET, but not with peak capacity or workload.View this table:Correlation of RVSWI and CPET ParametersConclusions: High right ventricular workload correlates with ventilatory inefficiency and impaired hemodynamics on CPET. Thus, exercise parameters may predict right ventricular work and LTx outcomes. ER -