RT Journal Article
SR Electronic
T1 LSC 2012 abstract - Surfactant protein A in chronic extrinsic allergic alveolitis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4529
VO 40
IS Suppl 56
A1 Martina Sterclova
A1 Martina Vasakova
A1 Peter Paluch
A1 Milan Paulik
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/4529.abstract
AB Chronic form of extrinsic allergic alveolitis (EAA) may have common features with idiopathic pulmonary fibrosis (IPF). The aim of presented study was to compare serum SP-A concentrations in IPF and chronic EAA patients and detect possible relationships of SP-A levels, bronchoalveolar lavage fluid (BALF) differential cell counts and high resolution computed tomography (HRCT) patterns in both diseases.Thirteen patients with chronic EAA and 7 patients with IPF were enrolled. All subjects underwent evaluation of SP-A serum concentrations, HRCT of the chest and BALF. HRCT alveolar and interstitial scores (HRCTa, HRCTi) were assessed according to Gay S1.EAA patients had significantly higher HRCT alveolar score then IPF group (p=0,003). Chronic EAA group exhibited positive correlation between HRCTi and BALF eosinophils (p<0,01) [Fig.1]. Serum SP-A concentrations did not differ between both groups.Our study shows that SP-A serum concentrations do not differ between chronic EAA and IPF patients and thus should not be used as a biomarker for IPF detection. Prognostic value of serum SP-A concentrations in chronic EAA patients should be the aim of further studies.1. Gay SE, et al. Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med 1998; 157:1063-72.