TY - JOUR T1 - High-dose inhalation corticosteroids in conjunction with plasmapheresis in the treatment of patients with acute variant of exogenic allergic alveolitis (EAA) JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P408 AU - Natalya Makaryants AU - Larisa Lepekha AU - Eugene Shmelev Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P408.abstract N2 - Aim: To evaluate efficacy of high-dose inhalation corticosteroids in conjunction with plasmapheresis in the treatment for acute variant of EAA.Materials and methods: We studied 16 patients with acute course of morphologically verified EAA. The main group (8 patients) received high-dose fluticasone (2500 μg) and plasmapheresis. The control group (8 patients) received the standard dose of prednisolone (0.25 mg/kg). The both groups received the treatment during one month. We performed cytology and morphology studies of lung biopsies from all the patients. We evaluated clinical symptoms (cumulative index), 6-minute walk test, spirometry, diffusing capacity of the lung, computed tomography (CT) of the lungs by Kazerooni, before and after the treatment.Results:View this table:To analyze the data we used the non-parametric methods of the Statistica programme, and the Wilcocson criterion.Conclusion: High-dose inhalation corticosteroids in conjunction with plasmapheresis may be used to treat patients with acute variant of EAA as alternative to the standard corticosteroid therapy. ER -