%0 Journal Article %A Patrick G. Linnane %A Thomas Voshaar %A Monica Spinola %A Alice Campanini %A Daniel Lock %A Mario Scuri %A Barbara Ronca %A Andrea S. Melani %T Usability evaluation of NEXThaler® versus Diskus® and Turbuhaler® %D 2012 %J European Respiratory Journal %P P1797 %V 40 %N Suppl 56 %X Inhaler device characteristics may impact real-world treatment effectiveness. NEXThaler® (Chiesi Farmaceutici) is a new dry powder inhaler (DPI) designed for persistent asthma with an innovative full dose feedback system incorporating a novel breath-actuated mechanism: a click is heard and a dose counter decrements by one count, only after effective full dose delivery. Effectiveness, efficiency and satisfaction are key components of device usability (ISO 13407:1999). NEXThaler®, Diskus® and Turbuhaler® were compared in a crossover trial in 66 asthmatic patients with no previous experience of using DPIs. After reading the patient information leaflet, patients performed two inhalations. Device-use errors and device preference were assessed through video recording and a standardized questionnaire.The proportion of patients completing both the first and second inhalation without making an error was significantly higher with NEXThaler® than Diskus® and Turbuhaler® (p<0.001) (Fig. 1A). Confidence that the dose had been successfully administered was greater with NEXThaler® than other DPIs (p<0.001) (Fig. 1B). Additionally, NEXThaler® was superior to both Diskus and Turbohaler in terms of ease of use (74 vs 17 and 9% respectively; p<0.001) and patient preference (75 vs 17 and 8%, respectively; p<0.001).Overall, effectiveness, efficiency and satisfaction measures each demonstrate that the usability of NEXThaler® is superior to Diskus® and Turbuhaler®. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P1797.full.pdf