RT Journal Article
SR Electronic
T1 NAT2 gene polymorphism in lung cancer: A study from north India
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3980
VO 40
IS Suppl 56
A1 Sandeep Bhattacharya
A1 Rajnikant Shukla
A1 Surya Kant
A1 Balraj Mittal
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3980.abstract
AB Purpose: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for Lung cancer, 2) to study possible association of tobacco smoking with NAT2 genotype of these patients.Materials and Methods: This case control study was undertaken over a period of 19 months and included 100 Lung cancer patients and 145 controls. The NAT2 genotypes were identified by PCR-RFLP method in peripheral blood DNA samples. Genotypes frequencies and the association of the genotypes among patients and controls group were assessed by χ2 test and Binary Logistic regression.Results: The NAT2 fast acetylator genotype frequency of slow or fast acetylator genotypes was not significant in lung cancer patients alone (OR = 1.18, 95% CI: 0.69 - 2.03, p value = 0.583).in non-smoker (OR = 1.06, 95% CI: 0.43 - 2.64, p value = 0.899) and smoker (OR = 1.32, 95% CI: 0.59 - 2.93, p value = 0.494) when compared with controls.Conclusion: These data demonstrate that the NAT2 fast or slow acetylators genotype did not associated with the risk of developing lung cancer in North Indian population when compared with controls.