RT Journal Article
SR Electronic
T1 Characterization of community acquired pneumonia (CAP) with severe sepsis at diagnosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1735
VO 40
IS Suppl 56
A1 Beatriz Montull Veiga
A1 Rosario Menéndez Villanueva
A1 Antoni Torres
A1 Soledad Reyes
A1 Rafael Zalacaín
A1 Alberto Capelastegui
A1 Javier Aspa
A1 Luis Borderías
A1 Juan José Martín-Villasclaras
A1 Salvador Bello
A1 Inmaculada Alfageme
A1 Felipe Rodríguez de Castro
A1 Jordi Rello
A1 Luis Molinos
A1 Juan Ruiz-Manzano
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1735.abstract
AB Background: CAP is a serious respiratory infection that may cause severe sepsis in around 30% of patients, thus increasing severity and mortality.Objective: To characterize patients who develop CAP with early or late severe sepsis at presentation.Results: A prospective multicentric cohort study was performed in 13 hospitals. Severe sepsis was diagnosed using Drenmsizov criteria (Chest 2006;129;968-978). 4,137 patients were included: 1,171(28.3%) without sepsis, 1,394(33.7%) with non severe sepsis and 1,572 (38%) with severe sepsis: 521(33.1%) of these had early (≥48 hours) and 1,051 (62%) late onset. There were no gender differences in early vs. late sepsis. Early sepsis was associated to elderly patients (≥65 years: 72.2% vs. 65.2%, p=0.006). Statistical differences in clinical presentation and comorbid conditions are depicted in Table 1. Early severe sepsis showed higher CURB65 scores than late sepsis (49.6% of patients vs. 41.5% with score 3).View this table:CAP with severe sepsis characteristicsConclusions: Early severe sepsis in CAP presents with greater severity while late onset does with large radiographic involvement. Diabetics, elderly patients and those with cerebrovascular disease are more prone to develop rapid onset severe sepsis in CAP.