TY - JOUR T1 - Characterization of community acquired pneumonia (CAP) with severe sepsis at diagnosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1735 AU - Beatriz Montull Veiga AU - Rosario Menéndez Villanueva AU - Antoni Torres AU - Soledad Reyes AU - Rafael Zalacaín AU - Alberto Capelastegui AU - Javier Aspa AU - Luis Borderías AU - Juan José Martín-Villasclaras AU - Salvador Bello AU - Inmaculada Alfageme AU - Felipe Rodríguez de Castro AU - Jordi Rello AU - Luis Molinos AU - Juan Ruiz-Manzano Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1735.abstract N2 - Background: CAP is a serious respiratory infection that may cause severe sepsis in around 30% of patients, thus increasing severity and mortality.Objective: To characterize patients who develop CAP with early or late severe sepsis at presentation.Results: A prospective multicentric cohort study was performed in 13 hospitals. Severe sepsis was diagnosed using Drenmsizov criteria (Chest 2006;129;968-978). 4,137 patients were included: 1,171(28.3%) without sepsis, 1,394(33.7%) with non severe sepsis and 1,572 (38%) with severe sepsis: 521(33.1%) of these had early (≥48 hours) and 1,051 (62%) late onset. There were no gender differences in early vs. late sepsis. Early sepsis was associated to elderly patients (≥65 years: 72.2% vs. 65.2%, p=0.006). Statistical differences in clinical presentation and comorbid conditions are depicted in Table 1. Early severe sepsis showed higher CURB65 scores than late sepsis (49.6% of patients vs. 41.5% with score 3).View this table:CAP with severe sepsis characteristicsConclusions: Early severe sepsis in CAP presents with greater severity while late onset does with large radiographic involvement. Diabetics, elderly patients and those with cerebrovascular disease are more prone to develop rapid onset severe sepsis in CAP. ER -