RT Journal Article SR Electronic T1 Mortality and morbidity after sleep disordered breathing JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 191 VO 40 IS Suppl 56 A1 Poul Jennum A1 Rikke Ibsen A1 Jakob Kjellberg YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/191.abstract AB The long-term prognosis of obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS), as compared to age, gender and social controls, are incompletely described.Using data from the Danish National Patient Registry (NPR) (1998-2010), 30278 individuals with a diagnosis of OSA (23208 men and 7070 women) and 1562 with a diagnosis OHS (1092 men and 470 women) were identified. For every patient, four ages-, sex- and social matched citizens were randomly selected from the Danish Civil Registration System, a total of 120506 OSA and 6241 HS controls. Morbidity and all-cause mortality was extracted from the NPR.The 10 year survival of treated and untreated OSA patients was 90.7% compared to 92.4% (controls) and of OHS patients 63.9% compared to 85.5% (controls) (both: p<0.0001).Commonly significant (p<0.01) observed morbidities in OSA patients OSA were related to respiratory (1.91 (1.82-2.01), nervous (1.65 (1.55-1.75), endocrine, metabolic, nutrietal (1.53 (1.54-1.75), ENT:1.39 (1.30-1.49), circulatory: 1.20 (1.16-1.27), musculoskeletal: 1,25 (1.20-1.30), digestive illnesses (1.09 (1.03-.14), and injuries 1.12 (10.8-1.16). Mental disease and neoplasm showed a lower occurrence: 0.90 (0.81-0.99) and 0.85 (0.80-0.95), respectively.OHS showed higher morbidities to respiratory: 4.03 (3.21-5.07), nervous: 3.17 (2.43-4.15), endocrine, metabolic, nutrietal (4.65 (3.67-5.90), ENT:1.39 (1.30-1.49), circulatory: 1.84 (1.50-2.26), musculoskeletal: 1,25 (1.20-1.30) and digestive illnesses (1.09 (1.03-.14), and injuries 1.12 (10.8-1.16). Neoplasm occurred less often: 0.70 (0.50-0.97).OSA and especially OHS present significant mortality. The morbidity includes a wide range of medical disorders beside cardiovascular complications.