RT Journal Article
SR Electronic
T1 Disturbance of airway patency is accompanied by a decrease of exhaled breath temperature in asthmatics
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3792
VO 40
IS Suppl 56
A1 Juliy M. Perelman
A1 Anna G. Prikhodko
A1 Nelly M. Smirnova
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3792.abstract
AB Introduction: Allergy in asthmatics is accompanied with the increase of exhaled breath temperature. The correlation of this parameter with airway patency is known little about.Aim: To study the correlation between bronchi patency and exhaled breath temperature in patients with bronchial asthma.Methods: The exhaled breath temperature (TºC) during quiet breathing using a device «X-halo» (Delmedica Investments Pte Ltd), lung function (FEV1, FEV1/FVC) and the level of hydrogen peroxide (H2O2) in exhaled breath condensate (EBC) were studied in 82 patients with bronchial asthma (the mean age 35.0±1.1 years).Results: The patients were divided into two groups according to the presence of airway patency impairment or its absence (FEV1 80.8±2.69 and 108.3±2.09%; p<0.001; FEV1/FVC 68.3±1.37 and 77.8±1.23%; p<0.001, respectively). In the group of patients with airway patency impairment there were a significant decrease of exhaled breath temperature (34.0±0.14°C) and the increase of H2O2 level (1.18±0.08nmole/ml) in EBC in comparison with the group of patients without lung function changes (34.5±0.14°C; p<0.05; 0.89±0.08 nmole/ml; p<0.05, respectively). There was found the correlation between the exhaled breath temperature and FEV1 (r=0.22; p<0.05) and the bronchodilation response to β2-agonist (ΔFEV1, r=-0.41; p<0.01), as well as between the level of H2O2 in EBC and FEV1 (r=-0.64; p<0.01).Conclusion: The decrease of exhaled breath temperature in asthmatics is associated with the disturbance of bronchial patency and reversibility of bronchial obstruction.