TY - JOUR T1 - Effect of arterial hypertension, obesity and overnight desaturation on plasma uric acid concentration in obstructive sleep apnoea (OSA) patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3191 AU - Robert Plywaczewski AU - Przemyslaw Bielen AU - Luiza Jonczak AU - Monika Targowska AU - Anna Czyzak-Gradkowska AU - Dorota Gorecka AU - Pawel Sliwinski Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3191.abstract N2 - OSA is often associated with obesity and metabolic syndrome. The aim of this study was to assess prevalence of hyperuricaemia in OSA patients and relations between elevated plasma uric acid (UA) and OSA severity, obesity and cardiovascular diseases. We studied 1144 OSA pts: AHI – 39.7±21.7, BMI – 34.2±6.4 kg/m2, mean SaO2 – 90.8±5.7%, T90 - 26.6±28.9%, Epworth score - 11.3±5.8 points. Hyperuricaemia [males: UA > 7 mg/dl (2005-2007) and > 8.5 mg/dl (since 2008), females: UA > 5.7 mg/dl (2005-2007) and > 6.2 mg/dl (since 2008) was found in 354 pts (30.9%) (different laboratory methods)]. Comparison of subjects with hyperuricaemia and normouricaemia is shown in table.View this table:Logistic regression analysis revealed that arterial hypertension, obesity (BMI > 30 vs ≤ 30 kg/m2) and T90 > 30% were independent predictors of hyperuricaemia (OR-1.76; 95%CI – 1.23-2.51; p=0.002, OR-2.47; 95%CI – 1.67-3.65; p<0.0001 and OR-1.79; 95%CI – 1.34-2.40; p<0.0001, respectively) after adjusting for NT-proBNP, diabetes, heart failure, coronary artery disease, COPD and stroke. Conclusions: Hyperuricaemia was frequent in OSA patients. Main predictors of hyperuricaemia were obesity, overnight desaturation time - T90> 30% and arterial hypertension. ER -