TY - JOUR T1 - Effects of a novel noninvasive open ventilation system during constant work rate exercise in COPD JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P600 AU - Janos Porszasz AU - Robert Cao AU - Richard Morishige AU - Richard Casaburi Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P600.abstract N2 - Exercise intolerance limits daily activities of COPD patients. Noninvasive ventilation improves exercise capacity in severe COPD, but previous systems are impractical for ambulatory use. This study evaluated a 0.45 kg noninvasive open ventilation (NIOV) system (Breathe Technologies), designed for nasal delivery of compressed O2 with each inhalation.This was a randomized single-blinded study of 10 men with severe-to-very severe COPD and exercise desaturation. Following a test day in which a cycle ergometer constant work rate (CWR) was established, subjects completed 3 additional days in which 2-3 CWR tests (separated by 1.5 hrs) were performed in random order. Tests were: unencumbered room air, NIOV+air, NIOV+O2, or O2 via standard nasal cannula. Data collected included exercise time, SpO2 and transcutaneous (Tc) PCO2.Subjects ages were 67±9y, with FEV1/FVC=29±6% and FEV1=30±12% pred. Compared to unencumbered and NIOV+air arms, endurance was prolonged ∼75% by nasal cannula O2 and ∼330% by NIOV+O2 (Table). The greater endurance in the NIOV+O2 tests was accompanied by higher SpO2 but unaltered TcPCO2.View this table:Responses to CWR exerciseExercise endurance was dramatically enhanced using the NIOV system+O2. These data suggest that this system is a practical means to improve tolerance of everyday activities in oxygen-dependent severe COPD. ER -