RT Journal Article
SR Electronic
T1 Oxidative stress in obese and nonobese patients with and without asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3394
VO 40
IS Suppl 56
A1 Leticia Hernandez-Cadena
A1 Fernando Holguin
A1 Albino Barraza-Villarreal
A1 Consuelo Escamilla-Nuñez
A1 Efrain Navarro-Olivos
A1 L.A. Brown
A1 L. Burwell
A1 Isabelle Romieu
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3394.abstract
AB RATIONALE: Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases.Alternatively, increasing BMI may lead to an increase in airway oxidative stress and obesity increases the riskfor developing new onset asthma in adults and children. Exhaled breath condensate (EBC) collection is anoninvasive method to investigate pulmonary oxidative stress biomarkers.METHODS: We measured exhaled nitrites and nitrites, 8-isoprostane, pH and oxidized (GSSG) glutathione,to assess alveolar oxidative stress in obese patients (52 asthmatics and 135 non-asthmatic) and 118 nonobese(52 asthmatics and 135 non-asthmatics). EBC was collected over 10 min using a refrigeratedcondenser according to European Respiratory Society/American Thoracic Society recommendations.RESULTS.187. We found an increase in the concentrations of GSSG and 8-isoprostanes in both groups ofobese patients (both asthmatic and non-asthmatics) compared with nonobese patient (asthmatic and nonasthmatic) (p <0.001) and a slight decrease in the pH of EBC in obese patients with asthma compared withthe rest (p <0.05). In relation to nitrites and nitrates were statistically lower in obese patients with asthma andwithout asthma than the total non-obese patients.CONCLUSIONS: Our results suggest that obesity leads to an increase proinflammatory mechanisms thatcould be associated with increased systemic inflammation and oxidative stress and may affect the status orcondition of asthma.