PT  - JOURNAL ARTICLE
AU  - Leticia Hernandez-Cadena
AU  - Fernando Holguin
AU  - Albino Barraza-Villarreal
AU  - Consuelo Escamilla-Nuñez
AU  - Efrain Navarro-Olivos
AU  - L.A. Brown
AU  - L. Burwell
AU  - Isabelle Romieu
TI  - Oxidative stress in obese and nonobese patients with and without asthma
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3394
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3394.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3394.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - RATIONALE: Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases.Alternatively, increasing BMI may lead to an increase in airway oxidative stress and obesity increases the riskfor developing new onset asthma in adults and children. Exhaled breath condensate (EBC) collection is anoninvasive method to investigate pulmonary oxidative stress biomarkers.METHODS: We measured exhaled nitrites and nitrites, 8-isoprostane, pH and oxidized (GSSG) glutathione,to assess alveolar oxidative stress in obese patients (52 asthmatics and 135 non-asthmatic) and 118 nonobese(52 asthmatics and 135 non-asthmatics). EBC was collected over 10 min using a refrigeratedcondenser according to European Respiratory Society/American Thoracic Society recommendations.RESULTS.187. We found an increase in the concentrations of GSSG and 8-isoprostanes in both groups ofobese patients (both asthmatic and non-asthmatics) compared with nonobese patient (asthmatic and nonasthmatic) (p <0.001) and a slight decrease in the pH of EBC in obese patients with asthma compared withthe rest (p <0.05). In relation to nitrites and nitrates were statistically lower in obese patients with asthma andwithout asthma than the total non-obese patients.CONCLUSIONS: Our results suggest that obesity leads to an increase proinflammatory mechanisms thatcould be associated with increased systemic inflammation and oxidative stress and may affect the status orcondition of asthma.