TY - JOUR T1 - A randomized study of bronchoscopic blockade of the affected part of a lung as a part the complex treatment of patients with drug-resistant pulmonary tuberculosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2703 AU - Sergey Sklyuev AU - Denis Krasnov Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2703.abstract N2 - At the present time in Russia, there are 60% of TB patients with unsatisfactory results of treatment by standard chemotherapy regimens with anti-TB drugs, and therefore there is permanent search for new treatment approaches to these patients.Scope and purpose: To assess and to analyze the impact of endobronchial-valve therapy on pulmonary function. According to the existing hypothesis, the implantation of an endobronchial valve and exclusion of the affected part from the tidal volume of the lung do not decrease pulmonary function indices.Methods: We have compared the efficacy of endobronchial-valve therapy with a standard therapy. Changes in rates of FEV1 were the reference points for the study. Of 68 enrolled patients, 33 were randomly assigned to receive endobronchial valves (EBV group) and 35 to receive standard medical care (control group).Results: Before procedures the initial level of FEV1 in the EBV group was 84.18%. In control group it was 85.74% (p = 0.749). After 1 month, there was a slight decline in FEV1 up to 81.12% in the EBV group, in comparison to the control group with maintaining the level of FEV1 equal to 84.34%. Thus, the difference of mean values between the groups was 3.22% (p = 0.187). After 8 months of treatment (after removal of endobronchial valves), FEV1 in the group of EBV was restored to 83.82% compared to 83.31% of the control group (p = 0.606).Conclusions: Endobronchial-valve treatment does not reduce pumonary function during the complex treatment of patients with drug-resistant pulmonary tuberculosis. ER -