TY - JOUR T1 - The influence of gene-gene interaction on the development of respiratory distress syndrome in the neonates JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P478 AU - Svetlana Kyryachenko AU - Natalia Gorovenko AU - Zoia Rossokha Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P478.abstract N2 - Background: The investigation of gene-gene interaction is necessary for understanding of pathogenic mechanism in the development of respiratory distress syndrome (RDS).The aim of this study was to evaluate the genes influence and their complex effect on the RDS development.Methods: We conducted a case-control study of 151 neonates with RDS and 110 healthy neonates. The I/D, A1166C, G308A, C677T polymorphism of ACE, AT2R1, TNF-a, MTHFR genes were detected using PCR and RFLP analysis. Statistical analysis was performed to assess the analyzed effects (program SPSS_17.0 and MDR_2.0).Results: The frequency of all investigated genotypes with mutant allele (except AC genotype of AT2R1 gene) was significantly higher among RDS cases.The statistical model including all investigated genotypes had high predictive value (Percentage Correct=72,8). We have found negative entropy which indicated independent effects of each gene.Conclusion: The investigated genes polymorphism is independent risk factor for the RDS development. The further research with including other prognostic factors may be useful for new approaches to preventive strategy. ER -