PT  - JOURNAL ARTICLE
AU  - Diana Ivanova
AU  - Serge Borisov
AU  - Alexander Ryzhov
TI  - Risk of serious adverse reactions during the treatment of new tuberculosis patients
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P2603
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P2603.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P2603.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background:Treatment of tuberculosis (TB) may be complicated by serious adverse reactions (SADRs). Correct risk assessment before the start of treatment enables to choose the right preventive strategy and thereby to reduce a frequency of SADRs. The aim was to determine the rates of and risk factors for SADRs during treatment of new TB patients.Methods200 HIV-uninfected new pulmonary TB patients admitted to Research and Clinical Center for TB control 2009 to 2011 were monitored for ADRs during the intensive phase of treatment. The median age was 28.0 (IQR 22-44) yrs, 93 were female, 108 were smear-positive, 172 received only first-line anti-TB drugs. ADRs having NCI CTCAE Grade 3-4 were recorded as serious. Multivariate logistic regression was used for risk assessment.ResultsSeventy-six (37.8%) experienced at least one SADR, to a total of 95 events (47 - hepatitis, 19 – allergic reactions, 14 - hyperuricemia, 7 – deafness). Female sex (OR = 2,11, 95%CI: 1.08-4.12), a smear-positive TB (OR = 2.08, 95%CI: 1.05-4.13), a cavity diameter > 30 mm (OR = 5.11, 95%CI: 1.44-18.12), a body mass index (BMI) <22 kg/m2 (OR = 2.31, 95%CI: 1.18-4.53) and a history of drug/food allergy (OR = 2.94, 95%CI: 1.33-6.49) were identified as risk factors for developing a SADR.ConclusionDuring anti-TB treatment more than the third part of new TB patients experienced SADRs (more often hepatitis and allergy). Female sex, a history of drug/food allergy, low BMI, smear-positive TB and large cavities are the risk factors associated with SADRs.