TY - JOUR T1 - Incidence of viral infections in patients with lung transplantation JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2447 AU - Pierre-Olivier Bridevaux AU - John-David Aubert AU - Paola Soccal AU - Thierry Rochat AU - Laurent Kaiser Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2447.abstract N2 - Lung transplant recipients (LTR) are at risk of respiratory viral infection (VI). Our goal was to characterize clinical factors associated with upper or lower respiratory tract VI, as well as the relation between VI and acute graft rejection (AR) in a cohort of LTR patients.MethodLTR patients (n=112) from Lausanne & Geneva University hospitals had systematic nasopharyngeal swabs (NPS) and when indicated bronchoalveolar lavage (BAL) with transbronchial biopsy (N visits=903). We screened 18 distinct respiratory viruses with rt-PCR during: a) seven 6-week investigator-driven screening period (n=570), b) regular (n=124) and c) emergency visits (n=209).ResultsDuring follow-up, 172/903 VI (19%) were identified in 68/112 (61%) LTRs with 34/276 infected BAL and VI rate was highest during emergency visits (p<0.01).View this table:Viral infection ratesRhinoviruses were most frequent both in NPS (n=85/138, 65%) and BAL (n=20/34, 59%). New symptoms were reported in 73% of VI. AR was not associated with VI nor initiation of AR therapy up to 3 months (both p=0.5). Association wa unchanged when restricted to VI other than rhinovirus.ConclusionViral infection rate is high among LTR and related to one third of emergency visits. In this study, common viral infection was not associated with acute rejection or initiation of acute rejection therapy within 3 months. ER -