PT  - JOURNAL ARTICLE
AU  - Amanda James
AU  - Ajit Thomas
AU  - Shahrad Taheri
AU  - Adel Mansur
AU  - Dev Banerjee
TI  - The impact of OSA on nocturnal hypoxia in obese patients with chronic asthma
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P888
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P888.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P888.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - BackgroundThere is increasing evidence that asthma, obesity and OSA co-exist with resulting increased usage of health care resources. This cohort may have worse asthma control due to increased nocturnal hypoxia augmentating airway and systemic inflammation. The prevalence of OSA and degree of hypoxia in obese patients with asthma remains unclear.MethodsA retrospective survey of obese patients with chronic asthma referred to the sleep clinic between 2009-2010 undergoing overnight sleep monitoring was undertaken using RemLogic software (in-hospital polysomnography). Scoring of the respiratory data was as per American Academy of Sleep Medicine (AASM) guidelines 2007. OSA was defined as an apnoea/hypopnoea index(AHI) of ≥5.0/hour and moderate-severe as ≥15/hr.Results26 patients (19 females) were analysed. Mean(SD) BMI =45.2(10.8)kg/m2. Mean(SD) age=45.1(12.2)yrs. Six had Type2 Diabetes Mellitus and 12 had hypertension. OSA was found in 12(46%), 7(27%) had moderate-severe OSA. Those with OSA were more likely to have T2DM (33vs12%). There was no significant difference in BMI between the two groups. Those with OSA: (median(IQR))AHI=21.5 (13-45)/hr were more hypoxic during the night compared to those without OSA (AHI=2 (0.9-3)/hr). Mean nocturnal O2 sats (Mean(SD)): 91.6%(3.4) vs 95.3(1.2) P=0.003, minimum O2 sats: 80.1%(11.8) vs 90.5%(2.0) P= 0.01.ConclusionsOSA is common in obese patients with chronic asthma. Patients with OSA in this group were more hypoxic during the night. Clinicians looking after obese chronic asthma patients should consider screening for OSA. Prospective studies are required to further establish the prevalence of OSA in obese asthmatic patients, and the value of CPAP in this group.