TY - JOUR T1 - Use of home non-invasive ventilation (NIV) in patients with ankylosing spondylitis (AS) JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2078 AU - Martina Mason AU - Rebecca Chadwick AU - Ian Smith Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2078.abstract N2 - BackgroundVentilatory impairment is a recognised extra-articular manifestation of AS. To our knowledge there are no published data describing home NIV in this condition.Aims and objectivesRetrospective assessment of home NIV in AS patients at a tertiary UK ventilatory support centre to determine i) indications for NIV, ii) physiological response to treatment and iii) compliance and survival.MethodsCase records of patients referred for consideration of NIV between 1993 and 2011 were retrospectively reviewed and information regarding the indication for NIV, demographics, co-morbidities, arterial blood gas analysis, pulmonary function, mean overnight oxygen saturation (SpO2), compliance and survival recorded.ResultsThe case notes of 18 patients (15 male, 64±9.2 yrs) were reviewed. Most commenced NIV in the context of acute respiratory decompensation (n=11; 61%). The most frequent indication for NIV was hypercapnia (PaCO2≥6.5, n=14; 78%). NIV led to a sustained decrease in PaCO2 from the baseline (p<0.05) and rise in the mean overnight oxygen saturation (p<0.05). Twelve patients have died (68%) with the median time to death from starting NIV of 31 months (range 1-98). The median duration of treatment was 33 months (range 1-99).View this table:ConclusionAS patients demonstrated good compliance with NIV, which was associated with a sustained improvement in physiological parameters. ER -