@article {DeleanuP4073, author = {Oana-Claudia Deleanu and Diana Pocora and Ruxandra Ulmeanu and Stefan Mihaicuta and Florin-Dumitru Mihaltan}, title = {The influence of active and former smoking on the amount and quality of sleep in an obstructive sleep apnea (OSA) population versus habitual snorers}, volume = {40}, number = {Suppl 56}, elocation-id = {P4073}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Purpose: Data regarding smoking-OSA relationship and sleep quality are inconsistent; studies are small, without adjustment for confounders (comorbidities, dependencies). Is known that acute withdrawal of nicotine causes sleep alteration, without dose-effect relationship.Objective: We analyzed effects of smoking and smoking status on sleep in 2 groups (OSA and habitual snorers) comparable regarding comorbidities and dependencies.Results: We analyzed 71 OSA patients (18\% women,82\% men) successfully CPAP titrated (other pathologies excluded): 25(35\%)nonsmokers, 19(27\%) active smokers (YP=21.5{\textpm}20.7,Fagerstrom=3.5{\textpm}2.1), 27(38\%) exsmokers (YP=25.9{\textpm}18.8); mean values: age=54.3{\textpm}13 years, Epworth=8.2{\textpm}5.4,total sleep time=5.6{\textpm}2h, arousal index=29.7{\textpm}23.7/h, AHI=38.1{\textpm}35.6/h. We compared OSA active smokers with control group of 11 active smokers snorers (2 women, 9 men, age=41.1{\textpm}11.7 years, Epworth=4.09{\textpm}3.6, YP=23.2{\textpm}22.5, Fagerstrom =4.6{\textpm}2.3, total sleep time=4.7{\textpm}2.3h, arousal index=15.8{\textpm}11.6/h). OSA smokers sleep quality is affected vs non-smokers (more arousals, p=0.02).There was no difference in total sleep time, efficiency, sleep latency, sleep stages or OSA severity (except worse nocturnal hypoxemia in active smokers: r= -0.49,p=0.03); no differences between active smokers/exsmokers, nor between OSA patients and snorers. YP index correlates with arousal index, but doesn{\textquoteright}t correlate with nicotine dependence.Conclusion: Smoking intensity and sleep quality (arousal index)correlated, unrelated to nicotine dependence. Studies are needed to prospectively assess effects of smoking on sleep and OSA using a non-snoring smokers control group.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P4073}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P4073.full.pdf}, journal = {European Respiratory Journal} }