PT  - JOURNAL ARTICLE
AU  - Robert Plywaczewski
AU  - Luiza Jonczak
AU  - Przemyslaw Bielen
AU  - Dorota Gorecka
AU  - Pawel Sliwinski
TI  - Cardiovascular diseases are responsible for increased plasma NT-proBNP level in obstructive sleep apnoea (OSA) patients
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3193
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3193.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3193.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Untreated OSA is a risk factor for cardiovascular morbidity and mortality. Brain natriuretic peptide (BNP) is a hormone secreted by the ventricles in response to heart overload. The aim of this study was to assess plasma NT-proBNP (inactive form of BNP) in OSA subjects and relationship between hormone level and OSA severity and complications. We studied 1145 OSA pts (859 males-75% and 286 females-25%), mean age - 56.4±10.4 years, AHI – 39.6±21.6, BMI - 34,2±6,4 kg/m2. Increased NT-proBNP (> 125 pg/ml) was found in 294 subjects (25.7%). Comparison of OSA subjects with normal and elevated NT-proBNP is shown in a table.View this table:Logistic regression analysis revealed that heart failure (OR- 4.4; 95%CI – 4.09-4.74; p<0.0001), atrial fibrillation (OR-4.22; 95%CI – 3.89-4.58; p<0.0001), coronary artery disease (OR-2.29; 95%CI – 2.16-2.43; p<0.0001), arterial hypertension (OR-1.87; 95%CI – 1.75-2.0; p<0.0001) and COPD (OR- 1.37; 95%CI – 1.27-1.47; p<0.0001) were independent predictors of increased NT-proBNP after adjusting for BMI, diabetes, hyperuricaemia and stroke.Conclusions: Increased plasma NT-proBNP concentration in OSA subjects was mainly related to cardiovascular diseases.