TY - JOUR T1 - Challenges in the management of patients with ANCA- associated vasculitides JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2376 AU - Ionela Nicoleta Belaconi AU - Claudia Lucia Toma AU - Stefan Dumitrache-Rujinski AU - Cornelia Tudose AU - Diana Leonte AU - Miron Alexandru Bogdan Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2376.abstract N2 - Background: Granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis are antineutrophil cytoplasm antibodies (ANCA) – associated vasculitides with significant morbidity and mortality.Objective: We evaluated the evolution of 12 patients diagnosed in our clinic between 2000 and 2011, treated with conventional treatment (prednisolone and pulse cyclophosphamide initially, and in remission with prednisolone and azathioprine).Results: We evaluated 12 patients (10 females), median age of 46 years (range 20-74), with a median duration of follow up of 5.2 years (range 1-12 years).Six patients had relapses (50%), 1 developed subglottic stenosis, 1 retro-orbital pseudo tumor and 2 patients developed lung abscesses inside a cavity which imposed lobectomy after unsuccessful antibiotic treatment. Two patients developed lung tuberculosis (one multi-drug-resistant) and 1 pulmonary nocardiosis linked to the immunosuppressive therapy. Two patients needed peritoneal dialysis for renal failure. Two patients died of stroke (1) and severe active vasculitis (1). Older age and renal failure were predictors of death.Conclusions: The management of patients with ANCA-associated vasculitides is difficult, and marked by significant adverse effects of the therapy. ER -