RT Journal Article
SR Electronic
T1 Improving inhalation parameters through dry powder inhalers (DPIs) after an acute asthma exacerbation
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1799
VO 40
IS Suppl 56
A1 Wahida Azouz
A1 Mokhtar El-Soussi
A1 Henry Chrystyn
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1799.abstract
AB All DPIs are passive inhalers because they require the generation of an internal energy (P) from an interaction between the patient's inhalation and the device's resistance to deaggregate the formulation in the metered dose. During acute exacerbations patient inspiratory effort will be reduced and thus P will be reduced. We have measured the inhalation profiles of 18 asthmatics, mean(SD) age 42.0(11.8) years, on days 1-4 following their admission with an acute exacerbation. These measurements have been made using a Diskus (DKS), Easyhaler (EASY) and Turbuhaler (TBH) - inhalers with medium, medium/high and high resistance.View this table:All parameters improved. PIF should not be considered in isolation and provides the wrong message, especially for high resistance DPIs, as PP and ACC are more important. The significance of the IV results needs to be investigated.