RT Journal Article
SR Electronic
T1 Determinants of relapse and survival in completely ressected non small cell lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4198
VO 40
IS Suppl 56
A1 Filipa Soares Pires
A1 Gabriela Fernandes
A1 Ana Paula Vaz
A1 António Morais
A1 Conceição Souto Moura
A1 Pedro Bastos
A1 Venceslau Hespanhol
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4198.abstract
AB INTRODUCTION: Lung ressection is the treatment of choice in Non-Small Cell Lung Cancer (NSCLC). Besides TNM staging, other features have been reported as significant prognostic factors.AIM: To analyze factors affecting relapse and survival in NSCLC after complete ressection.METHODS: A retrospective study was conducted, including patients with NSCLC completely ressected in the last 12 years. Clinical and histological factors were assessed and its influence on survival free of relapse and overall survival was determined.RESULTS: 160 patients were included, 77.5% male and 22.5% female, with a median age of 65years. Relapse occurred in 69 patients (median survival free of relapse - 56 months). At univariate analysis, an association was found between reduced survival free of relapse and age≤62 years, clinical tumor size≥4cm, clinical TNM stage>IB, clinical T>1, clinical N>0, pathological TNM stage>IB, pathological T>2, pathological N>0 and vascular invasion. At multivariate analysis, tumor size≥4cm (p=0.004), pathological TNM stage>IB (p=0.023) and vascular invasion (p=0.024) were associated to a reduced survival free of relapse.64 patients died (median overall survival – 112 months). At univariate analysis, an association was found between reduced overall survival and age≤62 years, clinical tumor size≥4cm, clinical TNM stage>IB, clinical N>0, pathological TNM stage>IB, pathological T>2, pathological N>0, vascular invasion and poor differentiation of tumor. At multivariate analysis, only pathological TNM stage>IB (p=0.029) remained associated a poorer overall survival.CONCLUSION: Besides TNM staging, other features are important on relapse and survival and should be considered for adjuvant therapy.