RT Journal Article
SR Electronic
T1 Outcomes of lung transplantation for bronchiectasis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2443
VO 40
IS Suppl 56
A1 Jodie Birch
A1 Katy Hester
A1 Gareth Parry
A1 Kate Gould
A1 John Dark
A1 Stephen Clark
A1 Gerard Meachery
A1 James Lordan
A1 Andrew Fisher
A1 Paul Corris
A1 Anthony De Soyza
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2443.abstract
AB Background: Non-cystic fibrosis bronchiectasis (nCFBr) is an infrequent indication for lung transplantation and poorly described compared to CF and COPD. We describe our experience in the largest series to date.Methods: Retrospective review of case-notes and transplant databases from1990 to date (22 years). Two time cohorts were set (1990-2000 and 2001-present date). Results: 43 patients with nCFBr underwent lung transplantation at our centre. 42 patients had bilateral lung and one had heart-lung transplantation. Median age at transplant was 48 years. Mean pre-transplant FEV1 was 22% predicted (range, 10%-49%; n= 38). At assessment 84% (32 of 38 complete datasets; 32/38) were in respiratory failure. Pre-transplant mean BMI was 25.2kg/m2 and osteoporosis was seen in 50% (15/30). Pseudomonas aeruginosa was isolated in 63% (22/35) at assessment and in 46% (18/39) at time of transplant. More patients were transplanted in the first cohort (n=26 vs. n=17). Mean pre-transplant FEV1 (% of predicted) were similar in both time cohorts (21% vs. 23%, p=NS) though patients transplanted in 1990-2000 were younger (mean; 45 vs. 51 years, p=0.026). Our survival values were 74% at 1 year, 64% at 3 years, 61% at 5 years and 48% at 10 years. Infection and multi-organ failure were common causes of death within 1 year post-transplant.Conclusions: P. aeruginosa infection is not universally seen in our cohort. Our survival rates are comparable to prior smaller nCFBr series (Beirne, P.A. et al. J Heart Lung Transplant 2005;24:1530-5) but are poorer than those for CF at our centre (Meachery, G. et al. Thorax 2008;63:725-731). Patients transplanted for nCFBr have significant osteoporosis rates and are increasingly older at transplantation.