RT Journal Article
SR Electronic
T1 Comorbidity by smokers - A cumulative effect of exogenic and endogenic factors?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4076
VO 40
IS Suppl 56
A1 Zlatka Iankova
A1 Rositsa Ivancheva
A1 Filip Sterev
A1 Vania Youroukova
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4076.abstract
AB This work is an analysis of our studies and literary data about a cumulative effect of tobaco smoke and another risk factors and comorbidity. There is investigated the conection between COPD and COPD and lung cancer (COPD + Ca):A. Clinicaly.There are follow up 120 smokers with COPD + Ca, 181 smokers with COPD, 50 with lung cancer and 50 health smokers (control group). We proved that: The number of smoked cigarettes (p = 0.009) and air polution at work environment (exogenic factors) are more risky about COPD + Ca than early beginning of tobaco smoke (p = 0.821). Predisposition about Ca is more risky than another diseases in family (14.17 %). Smokers with COPD + Ca and COPD more often have cardiovascular and metabolic diseases than this with lung cancer and control group. Predisposition in family about cardiovascular and metabolic diseases exeed the interval – 2 – 4 %, established with the control group and the group with lung cancer.B. Experimental. There is investigated lung and bone marrow in rats, treated with tobaco smoke for 30 days. We found a centroacinar emphysema with predominant destruction by massive exposition and bronchiolitis. The micronuclei (erythrocytes with nuclear chromatin) in bone marrow are significant higher compared with the control group (4.35 +/–0.5 / 1.58 +/– 0.33). This results showed that in conjunction with local lung changes occur systemic effects (clastogenesys as a result of cytotoxic effect).Conclusion: The comorbidity in relationship with tobaco smoke is related with a cumulative effect of exogenic and endogenic factors. There are necessary profound analysis to prove of releated with the cumulative effect of exogenic and endogenic factors comorbidity.