PT  - JOURNAL ARTICLE
AU  - Zlatka Iankova
AU  - Rositsa Ivancheva
AU  - Filip Sterev
AU  - Vania Youroukova
TI  - Comorbidity by smokers - A cumulative effect of exogenic and endogenic factors?
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4076
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4076.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4076.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - This work is an analysis of our studies and literary data about a cumulative effect of tobaco smoke and another risk factors and comorbidity. There is investigated the conection between COPD and COPD and lung cancer (COPD + Ca):A. Clinicaly.There are follow up 120 smokers with COPD + Ca, 181 smokers with COPD, 50 with lung cancer and 50 health smokers (control group). We proved that: The number of smoked cigarettes (p = 0.009) and air polution at work environment (exogenic factors) are more risky about COPD + Ca than early beginning of tobaco smoke (p = 0.821). Predisposition about Ca is more risky than another diseases in family (14.17 %). Smokers with COPD + Ca and COPD more often have cardiovascular and metabolic diseases than this with lung cancer and control group. Predisposition in family about cardiovascular and metabolic diseases exeed the interval – 2 – 4 %, established with the control group and the group with lung cancer.B. Experimental. There is investigated lung and bone marrow in rats, treated with tobaco smoke for 30 days. We found a centroacinar emphysema with predominant destruction by massive exposition and bronchiolitis. The micronuclei (erythrocytes with nuclear chromatin) in bone marrow are significant higher compared with the control group (4.35 +/–0.5 / 1.58 +/– 0.33). This results showed that in conjunction with local lung changes occur systemic effects (clastogenesys as a result of cytotoxic effect).Conclusion: The comorbidity in relationship with tobaco smoke is related with a cumulative effect of exogenic and endogenic factors. There are necessary profound analysis to prove of releated with the cumulative effect of exogenic and endogenic factors comorbidity.