RT Journal Article SR Electronic T1 Aerobic exercise training cannot be prescribed based on predictive heart rate equations in moderate or severe asthmatic patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1162 VO 40 IS Suppl 56 A1 Felipe Mendes A1 Renata Teixeira A1 Andrezza Pinto A1 Rafael Stelmach A1 Alberto Cukier A1 Milton Martins A1 Celso Carvalho YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1162.abstract AB Background: Recent studies have shown that physical training improves exercise capacity and health related quality of life (HRQoL) in asthmatics; however the best way to prescribe aerobic exercise intensity in these patients remains poorly known. Objective: To evaluate if predictive heart rate equations can be used to prescribe exercise intensity in subjects with moderate or severe asthma. Methods: Ninety-eight adults with moderate to severe asthma aged 36 (ranging from 24–53) years were submitted to a symptom-limited cardiopulmonary exercise testing (CPET) and anaerobic threshold (AT) was determined by two independent experienced reserchers. The association and agreement between maximum heart rate (HRmax) achieved on CPET and age-predicted Tanaka's maximum HR [208 – (0.7×age)] were evaluated, respectively, by Pearson's correlation and intraclass correlation coefficient. Similar analysis was applied between HR determined by CPET and heart rate reserve [(FCrest + 0.5 (HRmax-HRrest)], widely used to estimate exercise intensity at AT. Results: Maximal HR obtained by CPET was significantly lower than age-predictive equation (177.0 vs. 182.8 bpm, respectively, p<0.05). There was a weak correlation (p<0,001; r=0,46) and a weak agreement (p<0,001; ICC=0,26) between the achieved and estimated HRmax. At anaerobic threshold the HR obtained by CPET was similar to HR predicted equation (128 vs. 131 bpm, respectively, p>0.05), however, no correlation or agreement was observed between the HR (p>0.05). Conclusion: Exercise prescription for adults with moderate or severe asthma should be determined directly by an exercise test instead of using age-predicted equations.