@article {Nu{\~n}ezP3472, author = {Belen Nu{\~n}ez and M{\textordfeminine}. Rosa Julia and Jaume Sauleda and Antonio Clemente and Judith Garc{\'\i}a Aymerich and Josep Maria Anto and Alvar Agust{\'\i} and PAC-COPD study group}, title = {Antielastin antibodies in chronic obstructive pulmonary disease}, volume = {40}, number = {Suppl 56}, elocation-id = {P3472}, year = {2012}, publisher = {European Respiratory Society}, abstract = {IntroductionChronic obstructive pulmonary disease (COPD) is characterized by alterations in innate and acquired immune response. We have previously described an increased prevalence of circulating anti-tissue antibodies (AT) in COPD (Nunez et al AJRCCM 2011; 183: 1025). However, their antigenic specificity is unknown. Elastin is a potential antigen because antibodies against it have been described in these patients (Lee et al Nat Med 2007;13:567-569).HypothesisAll patients underwent clinical history, pulmonary function tests and blood collection following the methodology of the PAC-COPD cohort. The AT antibodies described in COPD patients show anti-elasting specificity.ObjectiveTo test this hypothesis we studied a cohort of 223 clinically stable COPD patients recruited into the PAC-COPD study (70 {\textpm} 8 years, FEV1/FVC 53 {\textpm} 13\%, FEV1 51 {\textpm} 15 \%ref, x {\textpm} SD) and a control population of 170 blood donors.Material and methodsAll patients underwent clinical history, pulmonary function tests and blood collection following the methodology of the PAC-COPD cohort. Elastin antibodies were quantified by ELISA.Results17.6\% of the COPD patients showed AT + titres >= 1/160; 3.1\% of patients with COPD and 4.7\% of controls had positive antibodies to elastin (p = ns).ConclusionsThe antigen specificity of the AT in patients with COPD does not correspond, by and large, to elastin.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P3472}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P3472.full.pdf}, journal = {European Respiratory Journal} }