TY - JOUR T1 - Correlations between disease-specific and generic health status questionnaires in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1465 AU - Sarah Wilke AU - Daisy J.A. Janssen AU - Emiel F.M. Wouters AU - Jos M. G. A. Schols AU - Frits M.E. Franssen AU - Martijn A. Spruit Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1465.abstract N2 - Purpose Aims of this longitudinal study were to determine whether and to what extent a disease-specific health status questionnaire correlates with generic health status questionnaires at 4 different time points in patients with advanced COPD; and to determine the correlation between the changes in these questionnaires during 1-year follow-up.Methods Demographic and clinical characteristics were assessed in 105 outpatients with advanced COPD. Disease-specific health status (Saint George's Respiratory Questionnaire, SGRQ) and generic health status (EuroQol-5-Dimensions, EQ-5D; Assessment of Quality of Life instrument, AQoL; Short Form-36, SF-36) were assessed at baseline, 4, 8 and 12 months. Correlations were determined between SGRQ and EQ-5D, AQoL and SF-36 scores and changes in these scores. Agreement in direction of change was assessed.Results 84 patients (80.0%) were included for analysis (61.9% male, age 65.7 (9.2) yrs, FEV1 34.2 (13.7)% pred). SGRQ total score and EQ-5D index score, AQoL total score and SF-36 Physical Component Summary measure (SF-36 PCS) score were moderately to strongly correlated (r = -0.49 to -0.68). The correlations of the changes between SGRQ and EQ-5D, AQoL, SF-36 PCS and SF-36 Mental Component Summary measure (SF-36 MCS) score were weak or absent (r = -0.13 to -0.27). The direction of changes in SGRQ agreed slightly with the direction of changes in EQ-5D, AQoL and SF-36 PCS score (Cohen's Kappa = 0.11 to 0.18, p<0.05).Conclusions Disease-specific health status questionnaires and generic health status questionnaires should be used together to gain complete insight in health status and changes in health status over time in patients with advanced COPD. ER -