PT  - JOURNAL ARTICLE
AU  - Nataliia Slepchenko
AU  - Yuriy Mostovoy
AU  - Andrii Sidorov
TI  - Is high level of IgE an additional problem in smoking patients with severe and very severe chronic obstructive pulmonary disease (COPD)?
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3441
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3441.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3441.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Smoking is one of the greatest risk factors of COPD and it increases the risk of allergic sensibilisation.The aim of the study was to estimate the level of IgE and its possible connection with the spirometric parameters and sensibilisation to allergens in smoking patients with severe and very severe COPD and great length of smoking.Methods. The 30 patients with very severe COPD were enrolled. It was estimated smoking status, body mass index (BMI), spirometric parameters (forced vital capacity (FVC), forced expired volume in 1 second (FEV1)) and level of total IgE. The skin prick test with local significant allergens (home dust, pollen of ambrosia, birch, fur of cat) was performed to patients with increased level of IgE.Results. The length of smoking was 28,5±6,8 pack-years. BMI was 26,9±2,5 kg/m². FEV1=41,5±8,9%, FVC=44,9±7,7%. The 24 patients had increased level of IgE (329,5±45,2 IU/l vs normal range is 0-87 IU/l). The 16 patients had sensibilisation to home dust and the 3 patients had sensibilisation to fur of cat. These patients also had periodically rash, itch, but they believed that symptoms are connected with COPD and did not ask for medical help to allergist. There is a strict correlative connection between the length of smoking and level of the IgE (r=0,8). There is a faint connection between the level of the IgE and FEV1 (r=0,2).Conclusions. The smoking patients with very severe COPD has allergic constitution with increased IgE level and sensibillisation to different allergens. There is no significant connection between level of IgE and spirometric parameters. Allergic symptoms in this category of patients need for attention.