RT Journal Article
SR Electronic
T1 Forced oscillation technique (FOT) reference values: Does one size fit all?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3205
VO 40
IS Suppl 56
A1 Claire Shackleton
A1 Albino Barraza-Villarreal
A1 Isabelle Romieu
A1 Claudia Calogero
A1 Graham Hall
A1 Peter Sly
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3205.abstract
AB Introduction: International reference ranges have been produced for spirometry. In comparison, current FOT reference values are limited to specific equipment and populations. We aimed to determine whether current reference values created from Australian and Italian children were applicable for Mexican children.Methods: Respiratory resistance (Rrs) and reactance (Xrs) were measured using FOT (Cosmed,Italy) in 585 children (292 males) 3-5 years old as part of a birth cohort in Mexico. Regression analysis determined factors predicting Rrs and Xrs at 6 and 8Hz and Zscores calculated. Calogero compared regression equations created in Italian children (3-6 years) to Australian children (4-6 years),with no significant difference reported in Rrs8 (p=0.43) and minor differences, which were within test variability, in Xrs8 (p=0.012). Based on this, Australian reference values were used for comparison. Zscores were calculated for the Mexican group using the derived regression equation. Zscores were also calculated for the Mexican group using the Australian reference values and the differences in these Zscores were compared using a paired t test.Results: Height was a significant predictor of Rrs and Xrs (p<0.05), but gender, age and weight were not (p>0.05). The Australian reference equation overestimated lung function in Mexican children (paired t-test) for Rrs and Xrs at 6 and 8Hz compared to data created using the Mexican equation (p<0.001).Conclusions: Despite similarities between current Australian and Italian FOT reference values these reference values are not valid for use in Mexican children aged 3-5 years. This highlights that one reference set from different parts of the world is not advisable for use in FOT.